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A widespread heterogeneity was the consequence: two functionally different immune systems both representing different types of barriers and each consisting of Astrocyte IL-6 IL-2 TNF ICAM-1 LFA-1 IL-6, IL-1, TNF-a GM-CSF TNF-a IL-1 ICAM-1 V-CAM-1 Microglia IL-6 T-Lymphocyte T-Lymphocyte CD8 IL-2 VLA-4 CD4 G-CSF Figure XVII-5.
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